Accession Number : AD0014625

Title :   INFLUENCE OF WHOLE BODY X-IRRADIATION, COLD EXPOSURE AND EXPERIMENTAL ACIDOSIS ON PROTEIN COMPOSITION AND AZORUBIN-BINDING CAPACITY OF RAT SERUM

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : WESTPHAL,ULRICH F. ; PRIEST,STANLEY G.

Report Date : 27 APR 1953

Pagination or Media Count : 11

Abstract : A significant reduction in total protein, albumin, and gamma globulin occurred in rat serum 2 and 3 days after a 22-min exposure to whole-body 880-r irradiation; sigma and Beta globulins were increased. The azorubin-binding capacity (ABC) of serum albumin was not affected by the exposure to irradiation, by an 18-day exposure to 4 deg C, or by acidosis produced by a 5 M NH4Cl solution administered by stomach tube in doses of 2 and 3 mM/100 g of body weight. The alterations in the N metabolism were similar to those of animals subjected to tourniquet shock or CCl4 treatment, but were not necessarily directly connected with differences in ABC.

Descriptors :   ACIDOSIS, ANIMALS, BODY WEIGHT, DOSAGE, EXPOSURE(GENERAL), GLOBULINS, IRRADIATION, METABOLISM, PROTEINS, SERUM ALBUMIN, STOMACH, TUBES.

Distribution Statement : APPROVED FOR PUBLIC RELEASE