Accession Number : AD0018099

Title :   RESEARCH ON CHEMICAL COMPOUNDS FOR THE INHIBITION OF GROWTH OF FUNGI

Corporate Author : FLORIDA UNIV GAINESVILLE ENGINEERING AND INDUSTRIAL EXPERIMENT STATION

Report Date : 30 JUN 1953

Pagination or Media Count : 1

Abstract : Oxine, cupferron, and salicylal derivatives, in addition to salicylal anils were screened for fungitoxicity as free chelating agents and/or as copper chelates. Compounds forming 5-membered chelate rings showed increasing toxicity with increasing stability. The reverse was true with 6-membered chelate rings. Copper chelates appeared more toxic than corresponding free chelates. A series of bisphenols showed no simple relationship between ionization constant and fungitoxicity. Experimental methods and data are presented for the determination of ionization constants of several chelating agents. Chlorinated derivates of cupferron were synthesized and studied. A new method was investigated for determining relative chelate stabilities of 2 chelating agents. An investigation was also made of the relationship of pH to fungitoxicity. Oxine was highly inhibitory to cresolase. A number of fungicides were tested as inhibitors of Myrothecium verrucaria but none were very effective. Radioactive oxine was prepared by placing the C14 in the benzene or heterocyclic ring. The latter was 4 times more active. The radioactive analyses were conducted using a modification of a new method of liquid counting. Mycelium of A. niger took up the greatest amount of oxine at pH 7. A. niger spores absorbed 100,000 times as much oxine, per unit weight, as did the mycelium. Radioactive spores were prepared by growing A. niger on a substrate 10-4 M in oxine. Experiments using radioactive oxine were carried out which paralleled the IR method of determining chelate stability.(See also AD-7634)

Descriptors :   , BENZENE, CHELATE COMPOUNDS, CHELATING AGENTS, CONSTANTS, COPPER, COUNTING METHODS, DETERMINATION, FILAMENTS, FUNGICIDES, HETEROCYCLIC COMPOUNDS, IONIZATION, LIQUIDS, PH FACTOR, PHENOLS, RADIOACTIVITY, RINGS, SPORES, TOXICITY, VEGETATION, WEIGHT.

Distribution Statement : APPROVED FOR PUBLIC RELEASE