Accession Number : AD0163755

Title :   Alpha Adrenergic Blocking Agents.

Descriptive Note : Patent,

Corporate Author : OFFICE OF THE SECRETARY OF THE ARMY WASHINGTON D C

Personal Author(s) : Heiffer,Melvin H. ; Jacobus,David P.

Report Date : 21 DEC 1971

Pagination or Media Count : 3

Abstract : The patent describes the pharmacological use of compounds having the following formula: H2N(CH2)mNH(CH2)nSY wherein m may be the integers 4 through 10 and n, 2 through 10, and SY is a sulfur containing function which may be metabolically converted to an --SH group, such as salts of thiols, phosphorothioic acid, thiosulfuric acid, alkyl thioethers, aryl thioethers, aralkyl thioethers and heteryl thioethers. The compounds of this invention are useful agents in blocking alpha-adrenergic mediated responses in animals; and in management of conditions such as hemorrhagic hypotensions, pheochromocytoma, and Raynaud's disease.

Descriptors :   (*PATENTS, SYMPATHOLYTIC AGENTS), (*SYMPATHOLYTIC AGENTS, *ALIPHATIC COMPOUNDS), (*ORGANIC SULFUR COMPOUNDS, SYMPATHOLYTIC AGENTS), HYPOTENSION, AMINES, EPINEPHRINE, LEVARTERENOL, ORGANIC PHOSPHORUS COMPOUNDS, HEMORRHAGE, BLOOD PRESSURE, DRUGS, PHARMACOLOGY

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE