Accession Number : AD0164840

Title :   Separation of Compounds Differing in Isotopic Composition.

Descriptive Note : Patent Application,

Corporate Author : DEPARTMENT OF THE AIR FORCE WASHINGTON D C

Personal Author(s) : Sievers,Robert E.

Report Date : 04 JUN 1974

Pagination or Media Count : 15

Abstract : The patent application describes the separation of compounds differing in isotopic composition by introducing a mixture of compounds into a chromatographic column containing a lanthanide chelate as a stationary phase. A fraction which is at least enriched with one of the compounds of the mixture is eluted from the column. The process is particularly applicable to the separation of a deuterated isomer from an isotopic mixture of organic compounds containing an electron donor group. The invention is based upon the discovery that two or more of such compounds differing only in isotopic composition, i.e., deuterium atom or atoms substituted for hydrogen atom or atoms, exhibit significant differences in the degree of interaction with the lanthanide chelates.

Descriptors :   *Isotope separation, *Column chromatography, *Deuterium compounds, *Rare earth compounds, *Chelate compounds, Metal complexes, Chromatographic analysis, Patents

Subject Categories : Organic Chemistry
      Physical Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE