Accession Number : AD0256242

Title :   BIOLOGICAL RECOVERY FROM RADIATION DAMAGE IN SMALL ANIMALS

Corporate Author : ARKANSAS UNIV LITTLE ROCK MEDICAL CENTER

Personal Author(s) : LANE,JOHN W. ; MAUDERLI,WALTER

Report Date : MAR 1961

Pagination or Media Count : 1

Abstract : Male, black C57 mice were exposed to multiple, small acute doses of gamma radiation from a Co60 source. Following a recovery period of one month, the dose required to result in a mean survival time of 30 days was determined. The differences in doses required for mice subjected to 600 and 1,200 r priming doses and that required in nonirradiated controls was seen to be 20% and 15.8% respectively. This residual radiation damage is felt to be high when compared to other reported data, and possible reasons for this are considered. A mathematical model is presented which describes radiation damage and its subsequent repair. An analog computer was utilized to study the possible curves resulting when the parameters and constants of the model were varied. These curves were compared to available experimental data and the contents for the best fit of the experimental points to the computer curves were determined. The results are promising, but more experimental data and further study of the analog computer curves are necessary. (Author)

Descriptors :   *ANIMALS, *RADIATION INJURIES, ANALOG COMPUTERS, COBALT, GAMMA RAYS, LABELED SUBSTANCES, MATHEMATICAL ANALYSIS, RECOVERY

Distribution Statement : APPROVED FOR PUBLIC RELEASE