Accession Number : AD0256294

Title :   THE INFLUENCE OF TISSUE PREPARATION AND PERIOD OF DRUG ACTION ON THE RESPONSE OF ISOLATED GUINEA PIG ILEAL SEGMENTS TO HISTAMINE DIPHOSPHATE

Corporate Author : NAVAL MEDICAL FIELD RESEARCH LAB CAMP LEJEUNE N C

Personal Author(s) : COOK,ELLZSWORTH B.

Report Date : APR 1961

Pagination or Media Count : 1

Abstract : ISOLATED ILEAL SEGMENTS FROM ALE GUINEA PIGS WERE EXPOSED TO FIVE LOGARITHMICALLY SPACED CONCENTRATIONS OF HISTAMINE DIPHOSPHATE. Tissue responses were measured at 1- and 3-minute intervals following the introduction of each concentration. No statistically significant differences were found between tissue responses at the 1- and 3-minute intervals. Responses were slightly more consistent 3 minutes after introduction of histamine. However, since the peak contraction occurred 1 minute following exposure to histamine, responses were better defined and simpler to measure at that interval. Statistically significant differences were found between preparations whose open lumen permitted free access of the drug to both internal and external surfaces and preparations whose closed lumen permitted wzdrug action only on the external surface. (Author)

Descriptors :   *HISTAMINE, *INTESTINES, *MUSCLE RELAXANTS, *TISSUES (BIOLOGY), HISTOLOGICAL TECHNIQUES, PHARMACOLOGY, PHOSPHATES, PREPARATION

Distribution Statement : APPROVED FOR PUBLIC RELEASE