Accession Number : AD0257482

Title :   BASIC QUANTITATIVE STUDIES OF SEVERE HYPOTHERMIA

Corporate Author : ROCHE PRODUCTS LTD WELWYN (ENGLAND)

Personal Author(s) : ADOLPH,E.F.

Report Date : 01 JUN 1961

Pagination or Media Count : 1

Abstract : Small mammals, especially rats, were exposed to cold air or to surface cooling. Adaptation was induced by significant colling, and four criteria of adaptation were employed to investigate its onset and decay. Hypothermia of 2 to 10 C could be endured for about 1 hr and at higher temperatures up to 25 C for progressively longer times, even 72 hours. In each instance survival after rewarming was required as criterion of endurance. Oxygen supply to tissues was especially investigated; oxygen was transported by the blood as long as the circulation continued, the heart usually reversibly ceased to beat at 7 C. But the oxygen was found not to reach all tissues, as was seen in the cessation of blood flow at 10 -15 C in some minute vessels, and in the frequent failure of a tissue oxygen electrode to vary its apparent oxygen tension when the lungs were filled with oxygen or with nitrogen. Several processes were affected disproportionately by cooling so that distortion among them resulted. (Author)

Descriptors :   *HYPOTHERMIA, BLOOD, COOLING, HEART, HEATING, INHIBITION, MAMMALS, METABOLISM, OXYGEN, OXYGEN CONSUMPTION, PHYSIOLOGY, RESPIRATION, STRESS (PHYSIOLOGY), SURVIVAL(PERSONNEL), TISSUES (BIOLOGY)

Distribution Statement : APPROVED FOR PUBLIC RELEASE