Accession Number : AD0259194

Title :   INJECTION OF A VOLATILE SUBSTANCE, ETHER, INTO THE BLOODSTREAM, AND ITS ELIMINATION FROM THE LUNGS

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s) : FEISAL,K.A. ; SONI,J. ; DU BOIS,A.B.

Report Date : 30 JUN 1961

Pagination or Media Count : 1

Abstract : The elimination in the lungs of a volatile liquid (ether) injected into the blood stream has been measured by means of a whole body plethysmograph, using dogs. The mean circulation time from the pulmonary artery to the vessels of gas exchange was 1.1 seconds. This was 28% of the pulmonary circulation time from pulmonary artery to leftATRIUM. The volume of gas evolved into the alveoli corresponded to that calculated from the partition coefficient and lung density. Reabsorption into the blood occurred slowly while the breath was held. If hyperventilation has been used, most of the ether injected would have been blown off from the lungs without ever reaching the systemic circulation. The application of this principle to other gases should be of interest, and may be predicted from the information obtained using ether. (Author)

Descriptors :   *BLOOD VESSELS, *ETHERS, *LUNG, DENSITY, EXCRETION, INJECTION, MEASUREMENT, METABOLISM, RESPIRATION

Distribution Statement : APPROVED FOR PUBLIC RELEASE