Accession Number : AD0260386

Title :   THE EFFECTIVENESS OF WATER-ELECTROLYTE REPLACEMENT THERAPY AND OF ANTIBIOTIC TREATMENT AGAINST ACUTE (3-5 DAY) INTESTINAL RADIATION DEATHS IN THE RAT

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : TAKETA,S.T.

Report Date : 22 JUN 1961

Pagination or Media Count : 1

Abstract : The influence of water and electrolyte replacement therapy and of treatment with antibiotics against acute (3-5 day) intestinal radiation deaths in rats exposed to an acute lethal dose of X-radiation has been studied. The administration of sterile 0.9% solution containing either NaCl or a mixture of NaCl, Na lactate, and KCl during the critical 2-5 days following irradiation had little, if any, protective effect. However, treatment with antibiotics (Combiotic P-S) during the same period definitely increased the number of survivors. The degree of protection was not affected by administering the antibiotics concurrently with sterile glucose solution, whereas, it was greatly enhanced when given simultaneously with a solution containing NaCl. These results strongly suggest that both dehydration and bacteremia are casually related in the genesis of acute (3-5 day) intestinal radiation in the rat. (Author)

Descriptors :   *ANTIBIOTICS, *BODY FLUIDS, *INTESTINES, *RADIATION INJURIES, *THERAPY, *X RAYS, DOSAGE, ELECTROLYTES (PHYSIOLOGY), LABORATORY ANIMALS, RADIATION EFFECTS, SURVIVAL(PERSONNEL), WATER

Distribution Statement : APPROVED FOR PUBLIC RELEASE