Accession Number : AD0261983

Title :   THE USE OF FAT EMULSIONS FOR INTRAVENOUS ALIMENTATION AND THEIR PHYSIOLOGIC EFFECT IN HUMANS

Corporate Author : CINCINNATI UNIV OHIO

Personal Author(s) : MUELLER,JOHN F. ; IACONO,JACK M.

Report Date : 18 AUG 1961

Pagination or Media Count : 1

Abstract : The so-called long-term reaction to intravenous Lipomul limits the usefulness of an otherwise acceptible fat emulsion. Anemia and hemorrhagic phenomenon are important components of the reaction. In an attempt to elucidate the mechanism of the complications our laboratory has attempted to study biochemical changes in the red blood cell and platelet which might appear prior to the full blown syndrome. Thus, patients with advanced, but not terminal, carcinoma have been infused with 12 daily 500 cc. bottles of Lipomul. The red cell and plasma fatty acids and the platelet phospholipids have been studied at appropriate intervals using a variety of available techniques. It has been possible to show that multiple infusions of Lipomul induce dramatic changes in the fatty acids of the blood. Linoleic acid rises precipitously while the other polyenes drop. Changes in the saturated fatty acids also occur. These changes do not occur when Lipomul is administered by oral route. The fact that the observed changes in red blood cells are reversible within 2-3 weeks indicates that this cell plays an active role in lipid transport under conditions of intravenous fat therapy and that such changes might be an etiologic factor in the anemia. (Author)

Descriptors :   *BIOCHEMISTRY, *COLLOIDS, *FATS, *PARENTERAL INFUSIONS, ANEMIAS, BLOOD PLASMA, BLOOD PLATELETS, CANCER, CHROMATOGRAPHIC ANALYSIS, ERYTHROCYTES, FATTY ACIDS, HEMORRHAGE, PHOSPHOLIPIDS, PHYSIOLOGY, VENOMS

Distribution Statement : APPROVED FOR PUBLIC RELEASE