Accession Number : AD0263254

Title :   EXPERIMENTAL CONDITIONS FOR ACUTE WHOLE-BODY IRRADIATION OF DOGS WITH COBALT 60

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : WANG, R.I.H. ; DAVIDSON, D.E. JR.

Report Date : 14 AUG 1961

Pagination or Media Count : 19

Abstract : Forty healthy, mature mongrel dogs of both sexes weighing 6.0 to 11.0 kg were exposed to doses of total-body cobalt 60 irradiation at midline tissue doses of 250 r and 500 r (27 to 32 r/min). Clinical examination and blood determinations of hematocrit, hemoglobin, total leucocyte, and differential count were obtained both prior to and following irradiation. Total leucocyte counts fell rapidly in all dogs. Hematocrit and hemoglobin levels decreased following irradiation. Recovery of the blood picture occurred in the dogs which eventually survived. Death of dogs when it occurred, fell between the eighth and twenth-sixth post-irradiation days. The mean survival time decreased as radiation dose was increased. The LD50/30 days for dogs irradiated in the single cage was estimated at 260 r and the LD100/30 days at 325 r. Dual cage irradiation resulted in an LD50/30 days of 335 r and an LD100/30 days of 400 r. (Author)

Descriptors :   *GAMMA RAYS, *RADIATION EFFECTS, DOGS, DOSAGE, DOSE RATE, LABORATORY ANIMALS, MEASUREMENT, PHYSIOLOGY.

Distribution Statement : APPROVED FOR PUBLIC RELEASE