Accession Number : AD0264472

Title :   STUDY OF STRUCTURES AND REACTIVITIES OF BOROXAZOLIDINES

Corporate Author : TEXAS A AND M UNIV COLLEGE STATION

Personal Author(s) : ZIMMERMAN,HOWARD K.

Report Date : 31 AUG 1961

Pagination or Media Count : 1

Abstract : The current status of boroxazolidine chemistry is reviewed. The predominant role of the steric requirements of N-substituted groups in determining the formation and stability of diptych and monocyclic boroxazolidines is thoroughly demonstrated through preparative experience withA WIDE RANGE OF REAGENT SYSTEMS, BY DIPOLE MOMENT DATA, AND BY STUDIES ON THE RATES OF N-B cleavage by boroxazolidines in acidic solutions. Acidic ionization constants over the temperature range from 15 to 55 C have been determined for phenyland n-butyl dihydroxyboranes and for diphenyl hydroxyborane, as well as for a series of N-substituted diethanolamine hydrochlorides. The relation of the ionization properties to structure is considered. The migrations of 69 aminoalcohols, each in three different solvent systems, have been determined on Whatman No. 1 paper. Pharmacological tests of nine boroxazo compounds have shown no significant useful results, but, on the contrary, have revealed a relatively high level of toxicity which is probably a consequence of the hydrolytic instability of the compounds tested. (Author)

Descriptors :   *CHEMICAL REACTIONS, *DRUGS, ACID BASE EQUILIBRIUM, CEPHALOPODA, CHEMICAL PROPERTIES, CHEMISTRY, IONIZATION, PHYSICAL PROPERTIES

Distribution Statement : APPROVED FOR PUBLIC RELEASE