Accession Number : AD0267228

Title :   CHOLESTEROL AND FATTY ACID BIOSYNTHESIS IN BRAIN

Corporate Author : MILAN UNIV (ITALY)

Personal Author(s) : GARATTINI,S. ; BIZZI,L.

Report Date : 31 JUL 1961

Pagination or Media Count : 1

Abstract : The problem of cholesterol biosynthesis in brain of suckling rats was studied. The effect of experimental conditions known to affect liver cholesterol and brain lipid synthesis was studied. The administration of Triton WR 1339 results in an increase of cholesterol synthesis in liver and, to a lesser degree, in brain when 1- C14 acetate, but not 2- C14 mevalonolactone, is used as precursor. Gamma-irradiation increases the cholesterol synthesis in liver but shows an opposite effect on such a synthesis in brain. After partial hepatectomy there is an increase of cholesterol synthesis in regenerating liver, using acetate as precursor, but no change occurs in brain. Exposure to low oxygen tension considerably decreases cholesterol synthesis in liver but shows no effect on brain. Thyroxine analogues, biphenylacetic acid derivatives, nicotinic acid, benzmalacene, MER-29, heparinoid and hexoestrol at various dose levels, do not affect the concentration of brain cholesterol. (Author)

Descriptors :   BIOSYNTHESIS, BRAIN, CHOLESTEROL, FATTY ACIDS, LABORATORY ANIMALS, LIPIDS, LIVER

Distribution Statement : APPROVED FOR PUBLIC RELEASE