Accession Number : AD0269533

Title :   EFFECT OF CATIONS ON RESISTANCE AND RESPONSIVENESS OF THE RENAL VASCULAR BED

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : FROHLICH, E.D. ; SCOTT, J.B. ; HADDY, F.J.

Report Date : 03 NOV 1961

Pagination or Media Count : 7

Abstract : The effect of the major cations on the resistance to blood flow through the kidney and whether these cations alter the renal vascular responsiveness to catecholamines was studied in dogs by perfusing the right kidney at a constant temperature and measuring the renal vascular pressure gradient during local infusions of isotonic cation solutions. Renal vascular pressure gradient increased with CaCl2, decreased with MgCl2, responded irregularly with KCl, and was not affected by NaCl. The renal arterial pressure response to intra-arterial injection of l-epinephrine or levarterenol was greatly attenuated during infusion of MgCl2. These findings suggest that a slight local elevation of serum calcium ion concentration produces active renal vascular restriction, that a similar elevation of magnesium ion reduces the constrictions produced by the catecholamines. (Author)

Descriptors :   *ARTERIES, *BLOOD CIRCULATION, *BLOOD PLASMA, *IONS, *KIDNEYS, CALCIUM, POTASSIUM, PRESSURE, SODIUM.

Distribution Statement : APPROVED FOR PUBLIC RELEASE