Accession Number : AD0270146

Title :   EFFECTS OF DRUG-INDUCED PERIPHERAL VASOCONSTRICTION AND VASODILATATION AND INCREASED HEAT PRODUCTION ON THE THERMAL AND METABOLIC RESPONSES OF DOGS EXPOSED TO COLD

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : BLATTEIS, CLARK M.

Report Date : 14 NOV 1961

Pagination or Media Count : 13

Abstract : A study was designed to determine whether resistance to cold can be augmented by suitable pharmacologic adjustments of the heat loss and heat production mechanisms. Aramine-induced peripheral vasoconstriction in dogs was ineffective in preventing body cooling in the cold. Arfonad-induced cutaneous vasodilatation was also without benefit in the cold because it increased peripheral cooling due to a greater dermal heat flow and it reduced heat production as a result of an inhibitory side-effect on respiratory metabolism. Metabolic Stimulator (DNP) was beneficial in the cold in that the enhanced metabolism caused an initial pyrexia which slowed the fall in body temperature. The data indicated that pharmacologic modification of the insulation of the skin to adjust heat loss patterns was without benefit in inducing cold resistance, while drug-enhanced heat production and pyrexia appeared to have a possible favorable action on the tolerance of cold. (Author)

Descriptors :   *ANTIMETABOLITES, *DRUGS, *EXPOSURE(PHYSIOLOGY), BODY TEMPERATURE, HEATING, OXYGEN CONSUMPTION.

Distribution Statement : APPROVED FOR PUBLIC RELEASE