Accession Number : AD0270592

Title :   INFLUENCE OF LARGE DOSES OF PYRIDOXINE HYDROCHLORIDE ON THE CONVULSIGENIC ACTIVITY OF UDMH IN MONKEYS

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : REEVES,JOHNIE L.

Report Date : DEC 1961

Pagination or Media Count : 1

Abstract : Earlier experiments, based on the finding that 1,1-dimethylhydrazine (UDMH) inhibited certain vitamin B6-requiring enzymes, showed that pyridoxine hydrochloride was very effective in either prophylaxis or therapy of UDMH-induced convulsions in rats. The current experiments show that pyridoxine hydrochloride is also an efficient antidote in monkeys. (Author)

Descriptors :   *ENZYMES, *METHYL HYDRAZINES, *VITAMIN B COMPLEX, INHIBITION, THERAPY

Distribution Statement : APPROVED FOR PUBLIC RELEASE