Accession Number : AD0276139

Title :   THE EFFECT OF WHOLE BODY X-IRRADIATION ON BLOOD PRESSURE IN THE RAT

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : PHILLIPS,R.D. ; KIMELDORF,D.J.

Report Date : 08 MAY 1962

Pagination or Media Count : 1

Abstract : Blood pressure was measured at a peripheral and central site in the rat. Pressure at the peripheral site was determined by a tail occlusion cuff method, while central pressure was measured by aortic intubation. There was a marked decrease in blood pressure measured at the peripheral sit 8 hours after the animals were exposed to 485 rads of x-rays, with a return to control values by 3 days after exposure. Aortic blood pressure, however, was not altered at this dose level. There was a mild decrease in aortic pressure 24 and 48 hours after 970 rads and a marked hypotension 8 and 24 hours following 1940 rads. The aortic blood pressure response to various stimuli was also altered after 970 rads, but not after 485 rads of x-rays. These data demonstrate that blood pressure at a peripheral site can be decreased at a dose level which does not affect central pressure. It is suggested that this differential effect in blood pressure is a result of a radiation response in peripheral circulation. (Author)

Descriptors :   *BLOOD PRESSURE, *CARDIOVASCULAR SYSTEM, *RADIATION EFFECTS, DOSE RATE, HYPERTENSION, LABORATORY ANIMALS, MEASUREMENT, X RAYS

Distribution Statement : APPROVED FOR PUBLIC RELEASE