Accession Number : AD0277818

Title :   THE CHEMISTRY OF RYANODINE.

Descriptive Note : Final rept. Apr 59-Aug 61,

Corporate Author : CALIFORNIA UNIV BERKELEY

Personal Author(s) : Rapoport,Henry

Report Date : 01 MAR 1962

Pagination or Media Count : 9

Abstract : Structure studies were carried out on ryanodine, an alkaloid which causes irreversible muscle contraction. Hydrolysis gives ryanodol and 2-pyrrolecarboxylic acid. Ryanodol was oxidized by periodic acid to give a crystalline, three-mole oxidation product. Ryanodol also was reduced by P and HI to a crystalline, benzenoid gamma-lactone. Aromatization studies on these products yielded a series of naphthalenes and anthracenes. A number of 2-pyrrolecarboxylic esters were prepared from 2-pyrrolecarboxylic acid chloride and the corresponding alcohol. (Author)

Descriptors :   CHEMICAL PROPERTIES, CHEMICAL REACTIONS, CHEMISTRY, CHROMATOGRAPHIC ANALYSIS, DEHYDROGENATION, HYDROGEN COMPOUNDS, HYDROLYSIS, IODIDES, MOLECULAR STRUCTURE, OXIDATION, PHOSPHORUS, PURIFICATION

Distribution Statement : APPROVED FOR PUBLIC RELEASE