Accession Number : AD0278530

Title :   EFFECT OF AMBIENT TEMPERATURE AND CHLORPROMAZINE TREATMENT ON RESISTANCE OF MICE CHALLENGED WITH KLEBSIELLA PNEUMONIAE

Corporate Author : ARCTIC AEROMEDICAL LAB FORT WAINWRIGHT ALASKA

Personal Author(s) : MARCUS,STANLEY ; MIYA,FRED

Report Date : OCT 1961

Pagination or Media Count : 1

Abstract : The hypothesis that increased metabolic rates enhance the host resistance to infection was investigated. Chlorpromazine was used to induce the state of hypothermic stress without compensatory increase in metabolic rates. The results of the experiments showed that the ambient environment influences the toxicity of the drug itself. Chlorpromazi e enhanced the death of mice challenged with Klebsiella pneumoniae, and an interpreta ion could be that the lowering of metabolic rates as a result of the drug injection was contributory to this effect. (Author)

Descriptors :   BODY TEMPERATURE, CHLORPROMAZINE, HYPOTHERMIA, MEASUREMENT, METABOLISM, TEMPERATURE, THERAPY, TOXICITY

Distribution Statement : APPROVED FOR PUBLIC RELEASE