Accession Number : AD0282910

Title :   STATIONARITY EQUATIONS IN CONTINUOUS TIME MARKOV CHAINS

Corporate Author : STANFORD UNIV CALIF APPLIED MATHEMATICS AND STATISTICS LABS

Personal Author(s) : MILLER,RUPERT G. JR.

Report Date : 27 JUL 1962

Pagination or Media Count : 1

Abstract : Solution of human serum albumin in a concentration of 17 to 22 g/100 ml and of dextran (M.W. 40,000) in concentration of 15 to 21 g/100 ml protect an average of 93.5% of the red cells from damage during rapid freezing and thawing. Microcytic cells under certain experimental conditions withstand the trial of rapid freezing and thawing better than normocytic cells. The molecular weight of dextran has no effect on the recovery of red cells after freezing and thawing, when used in optimal concentrations. Red cells frozen and thawed with the addition of albumin or dextran in the range of concentration noted above show poor posttransfusion survival in humans. Treatment with lactose prior to freezing with albumin, resulting in a final concentration of about 2% lactose or less, shows a very considerable improvement in the in vivo survival. (Author)

Descriptors :   *PROBABILITY, STATISTICAL PROCESSES

Distribution Statement : APPROVED FOR PUBLIC RELEASE