Accession Number : AD0283277

Title :   LOCAL EFFECT OF AMP, ADP, AND ATP UPON SMALL AND LARGE VESSEL RESISTANCE

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : FROHLICH, EDWARD D.

Report Date : 08 JUN 1962

Pagination or Media Count : 10

Abstract : An experiment was designed to study the effect, and localize the site of action, of the phosphorylated derivatives of adenosine on the vascular segments of the dog forelimb. A pre-calibrated blood pump was used to hold blood flow to the forelimb constant while pressures in the brachial artery, cephalic vein, and a small artery and vein in the forepaw were recorded. Isotonic solutions of AMP, ADP, and ATP were infused into the perfusion tubing at various rates. Acute local elevation of plasma AMP, ADP, and ATP concentration greatly decreased resistance to blood flow in the small vessels. It is concluded that AMP, ADP, and ATP act primarily on arterioles to produce active vasodilatation, and that, when administered locally, the latter two agents are probably equipotent, producing greater dilation than AMP. (Author)

Descriptors :   *ADENOSINE PHOSPHATES, *VASOACTIVE AGENTS, ARTERIES, LABORATORY ANIMALS, MUSCLES, PHARMACOLOGY, RELAXATION (PHYSIOLOGY).

Distribution Statement : APPROVED FOR PUBLIC RELEASE