Accession Number : AD0284494

Title :   OXYGEN CONSUMPTION BY THE ISOLATED RAT LIVER, EFFECTS OF HEMATOCRIT, TEMPERATURE, PERFUSION RATE AND OXYGEN TENSION

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : BRAUER,R.W. ; LEONG,G.F. ; HOLLOWAY,R.J.

Report Date : 24 JUL 1962

Pagination or Media Count : 1

Abstract : H EPATIC OXYGEN UPTAKE IN THE R T APPEARS TO BE F R ORE RAPID THAN RE LIZ D H RETOFOR , A , ON TH BASIS OF T E PRES NT RESULTS, IS LIKELY TO CONTRIBUTE ABOUT <%% to the basal metabolic rate of t is species. S veral lines of inv stigation point to a peculiarity in the oxygen delivery from the circulating erythrocytes to the parenchymal cells of the liver, a relation not readily explainable in terms of the conventional concept of oxygen diffusion through an aqueous phase, inert or re piring. Comp riso of th effects of perfusion rate and of oxygen saturation changes on the rate of hepa ic oxygen consumption leads to a paradoxical situation unless one hypothesizes that the hepatic cell population is heterogeneous with respect to the dependence of cell respiration on oxygen delivery. This heterogeneity, it is suggest d, is represented by the zon l differenti tion b tween peripheral and centrilobular liv r cells. (Author)

Descriptors :   *LIVER, *OXYGEN CONSUMPTION, LABORATORY ANIMALS, TEMPERATURE

Distribution Statement : APPROVED FOR PUBLIC RELEASE