Accession Number : AD0284495

Title :   LATE EFFECTS STUDIES ON RADIATION-INDUCED HOMOLOGOUS MOUSE CHIMERAS: LONGEVITY AND INCIDENCE OF LEUKEMIA

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : DAVIS,W.E. ; COLE,L.J.

Report Date : 26 JUL 1962

Pagination or Media Count : 1

Abstract : In studies on lymphoid cell chimerism and homograft tolerance in long-lived homologous radiation chimeras, data were collected on life span, and on leukemia and other lesions. The chimeras were hybrid mice (10 - 12 weeks old) exposed to 880 rad of X radiation and injected with bone marrow cells from C3H donors. Out of 119 mice, 65% were dead by age 32 weeks, with symptoms of second ry disease evident in the great majority. Relatively few deaths occurred between 32 and 75 weeks, and the maximum life span was 105 weeks. Histopathological data were obtained from many of these long-lived chimeras. There was an 80% incidence of glomerulosclerosis of moderate to severe degree, and a 20% incidence of arteriolarsclerosis in t e kidney and spleen. Leukemias were observed in 5 out of 54 homologous chimeras. Also, two leukemias occurred in 13 chimeras (15%) which had been injected with lymphoid cells obtained from other long-lived homologous chimeras. The possibility of a causal relationship between s condary disease and the increased incidence of leukemia is briefly discussed. (Author)

Descriptors :   *BONE MARROW, *LEUKEMIA, *X RAYS, ATHEROSCLEROSIS, COMMUNICABLE DISEASES, GENETICS, KIDNEYS, LABORATORY ANIMALS, MICE, NEOPLASMS, PATHOLOGY, RADIOPROTECTIVE AGENTS, SPLEEN

Distribution Statement : APPROVED FOR PUBLIC RELEASE