Accession Number : AD0284564

Title :   THE EFFECT OF A HIGH PROTEIN DIET UPON THE RENAL CONCENTRATING RESPONSE TO VASOPRESSIN AND TO DEHYDRATION OF APLODONTIA RUFA AND THE DOMESTIC RABBIT.

Descriptive Note : Annual progress rept., 1 Jan-1 Sep 62,

Corporate Author : MONTANA STATE UNIV MISSOULA

Personal Author(s) : Pfeiffer,E. W.

Report Date : 12 SEP 1962

Pagination or Media Count : 19

Abstract : Eight Aplodontia rufa and 10 rabbits were fed high and low protein diets. Plasma and urine urea-nitrogen concentrations were higher in both species which were fed a high protein diet. Seven A. rufa which were given 1% urea in the drinking water had the highest plasma urea-nitrogen concentrations. High protein-fed rabbits achieved a higher urine concentration and maximum urine-plasma osmolality ratio in response to vasopressin injection during water diuresis than those fed a low protein diet, but there was no difference in the urine concentration and maximum urine/plasma osmolality ratio in vasopressin injected A. rufa that were fed a high protein diet, urea loaded, or fed a low protein diet. Six high-protein-fed A. rufa subjected to dehydration had the same urine concentration as those fed a low protein diet. The role of urea in urine concentration is discussed and it is postulated that the lack of looped vasa recta in the renal medulla of A. rufa may be a factor in the inability of urea to increase the renal concentrating ability in this species. (Author)

Descriptors :   *KIDNEYS, *PITUITARY HORMONES, *URINE, BLOOD VESSELS, DIET, HISTOLOGY, KIDNEY FUNCTION TESTS, LABORATORY ANIMALS, PROTEINS, RABBITS, RODENTS, UREA, WATER PRIVATION

Distribution Statement : APPROVED FOR PUBLIC RELEASE