Accession Number : AD0286580

Title :   EFFECT OF X-RAY RADIATION AND PROPHYLACTIC TREATMENT WITH PROPYL GALLATE ON NUCLEIC ACID CONTENT IN RAT ORGANS

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : LIPKAN,M.F. ; BARABOY,V.A. ; LUKASHOVA,R.G.

Report Date : 12 SEP 1962

Pagination or Media Count : 1

Abstract : X-ray irradiation with a dose of 750 r depresses the nucleic acid (NA) level in the liver, spleen, intestinal ucosa (small intestines) and testicles of white rats. This decrease, which follows a regular pattern, is one of the principal factors responsible for the death of the animals. In surviving rats the NA level is not restored within a period of one month. The reduction of the RNA content in the organs of irradiated rats precedes that of DNA. The restoration also begins with RNA. Curves of the DNA decrease in the organs of irradiated animals correspond to their death curves. Injection of healthy rats with propyl gallate (PG) induces a change in NA content: It is first lowered, then restored. Variations of RNA precede those of DNA. The lowering of the NA level noted on the 3rd day in the liver, spleen and intestinal mucosa of irradiated rats injected with a preventive dose of PG is more marked than the decrease caused by PG or X-ray irradiation acting separately. Propyl gallate stimulates nucleic metabolism in irradiated animals. The effect becomes apparent at late stages following irradiation (on the 7th-30th day). The action results in accelerated, more complete restoration of the normal NA level. This regularity of PG activity is one of the factors related to its protective effect in acute radiation sickness. (Author)

Descriptors :   *BENZOATES, *NUCLEIC ACIDS, *RADIATION EFFECTS, *RADIOPROTECTIVE AGENTS, HYDROXIDES, INTESTINES, LABORATORY ANIMALS, LIVER, PROPYL RADICALS, SEX GLANDS, SPLEEN, TISSUES (BIOLOGY), X RAYS

Distribution Statement : APPROVED FOR PUBLIC RELEASE