Accession Number : AD0286748

Title :   RESEARCH ON PROCEDURES FOR THE LOW-TEMPERATURE PRESERVATION OF BLOOD. V. RED CELL VIABILITY STUDIES IN MAN AND RABBITS USING BLOOD FROZEN WITH GLUCOSE AND LACTOSE-GLUCOSE AS PROTECTIVE ADDITIVES

Corporate Author : UNION CARBIDE CORP TONAWANDA N Y LINDE DIV

Personal Author(s) : RINFRET,A.P.

Report Date : 01 APR 1961

Pagination or Media Count : 1

Abstract : The viability of human erythrocytes preserved by rapid free ing and thawing was assayed by procedures including an independent measure of blood volume. The viability of glucose-treated erythrocytes appears to be related to the a ount of additive used and the tim it remains in liquid state con act with t e cells before freezing. Longer periods of equilibration, while yielding higher red cell recovery following thawing, resulted in heavy osmotic destruction of cells on re ching the recipients' circulation. Rabbit ery hrocyt s treated with glucose additive showed poorer recovery following thawing than did human red cells. (Author)

Descriptors :   *BLOOD, *ERYTHROCYTES, ADDITIVES, BLOOD TRANSFUSION, BLOOD VOLUME, FREEZING, GLUCOSE, LABELED SUBSTANCES, LACTOSE, LOW TEMPERATURE RESEARCH, HUMANS, RABBITS, VIABILITY

Distribution Statement : APPROVED FOR PUBLIC RELEASE