Accession Number : AD0286956

Title :   PHARMACOLOGICAL STUDY ON CENTRAL SYNAPTIC SYSTEMS AFFECTING MOTOR FUNCTION

Corporate Author : MISSISSIPPI UNIV JACKSON SCHOOL OF MEDICINE

Personal Author(s) : ANDERSON,SAMUEL D. ; HOLLAND,WILLIAM C.

Report Date : 01 OCT 1962

Pagination or Media Count : 1

Abstract : A series of compounds with known activity in regard to their actions on synaptic reflexes and the central nervous system were investigated. Agents that are skeletal muscle relaxants act by depressing or interrupting transmission of nerve impulses through polysynaptic pathways. Included in this group of compounds are zoxazolamine and mephenesin. These agents also act on brain stem and subcortical areas. They have no direct effect on myoneural junction and, in lower concentration, no effect on monosynaptic pathways. The muscle relaxant properties of a number of compou ds were studied. In addition to their effects on neuro-muscular activity, these substances also have pronounced effects on the central nervous system, as evidenced by increased respiratory rate changes in temperament, and pubil size. In continuing these studies, we have confin d our attention to the CNS effects of one particular substance, Compound No. 6. Attempt were made to screen po sible antago ist . The possible antagonistic actions of tetrahydroamino acridine (THA) and physostigmine sulfate were studied in detail. (Author)

Descriptors :   *BRAIN, *MUSCLE RELAXANTS, ACRIDINES, AMIDES, ANTIHISTAMINICS, ANTIMETABOLITES, ATTITUDES(PSYCHOLOGY), DOSAGE, OXIDOREDUCTASES, PHARMACOLOGY, PHYSOSTIGMINE

Distribution Statement : APPROVED FOR PUBLIC RELEASE