Accession Number : AD0287075

Title :   ADDITIVE EFFECTS OF ACETAZOLAMIDE AND FAT EMULSION ON THE A-A B(CO2) DIFFERENCE

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : CAIN,STEPHEN M.

Report Date : APR 1962

Pagination or Media Count : 1

Abstract : Alveolar and arterial gas tensions (P) were measured in anesthetized dogs during a control period, after intravenous injections of a carbonic anhydrase inhibitor, and after rapid intravenous infusion of fat emulsion. The alveolararterial (A-a) P(CO2) difference increased from about 6 mm. Hg during the control period to 26 mm. Hg after carbonic anhydrase inhibition. A further increase took place after fat emulsion when the A-a P(CO2) difference averaged 35 mm. Hg. There was no increase in the A-a P(O2) difference between carbonic anhydrase inhibition and fat emulsion. The additive increase in the A-a P(CO2) difference strongly suggested that fat emulsion did not further interfere with the interconversion of CO2 and bicarbonate. (Author)

Descriptors :   *CARBON DIOXIDE, *CARBONIC ANHYDRASE, *FATS, ARTERIES, BLOOD, DIURETICS, LABORATORY ANIMALS, LUNG, VEGETABLE OILS

Distribution Statement : APPROVED FOR PUBLIC RELEASE