Accession Number : AD0287206

Title :   BIOLOGIC RESPONSE TO POLYURETHANE FOAM

Corporate Author : TENNESSEE UNIV KNOXVILLE

Personal Author(s) : SHERMAN,R.T.

Report Date : 31 OCT 1961

Pagination or Media Count : 1

Abstract : Summary of general and specific toxicity in mice, rats, and dogs of prepolymers, catalysts, and polymerized polyurethane measured by several methods reveal the relative lack of toxicity of these compounds within the experimental framework described. Studies of C14 ring labelled polyurethane implanted into rat tibias indicate beginning mobilization from the site of implant at approximately 30 weeks post implant. Preliminary estimates of activity of visceral homogenates suggest increase in total activity over background in spot checks of homogenate of an animal at 15 months. Stools and urine of implanted rats are negative for radioactivity. Studies of specific organ activity are in progress. No evidence of carcinogenicity in rats implanted by polyurethane rods (tibia and dorsal subcutaneous) has appeared during 685 days of observation post implant. Methods of C14 tagging and sample preparation of polyurethane compounds are detailed. (Author)

Descriptors :   *EXPANDED PLASTICS, *SURGERY, *TRANSPLANTATION, *UREIDO ( N-C( O)-N, LABELED SUBSTANCES, LABORATORY ANIMALS

Distribution Statement : APPROVED FOR PUBLIC RELEASE