Accession Number : AD0288021

Title :   SYSTEMIC EFFECTS PRODUCED BY PHOSPHOLINE IODIDE IN TREATMENT OF GLAUCOMA

Corporate Author : COLORADO UNIV DENVER MEDICAL CENTER

Personal Author(s) : HUMPHREYS,JOHN ; HOLMES,JOSEPH H.

Report Date : DEC 1961

Pagination or Media Count : 1

Abstract : In 102 cases of glaucoma, pilocarpine or DFP therapy red cell cholinesterase values did not differ significantly from those obtained in a group of 586 normals. In 24 patients on phospholine iodide therapy a reduction in red cell cholinesterase occurred in 87.5% and was presumed indicative of systemic absorption. Systemic symptoms considered typical of anticholinesterase exposure were present in 9 cases and all had a marked reduction in the red cell cholinesterase. Six cases had a marked reduction in red cell cholinesterase without symptoms. There was a definite correlation between the length of therapy, the dosage and the degree of reduction in red cell cholinesterase. It was proposed that the red cell cholinesterase values should be used as an index of systemic absorption and thus allow the physician to adjust therapy in order to prevent the appearance of symptoms. The findings should be used as an aid in differential diagnosis to distinguish between symptoms caused by these organic phosphorus compounds and by other causes. The use of 2 PAM for treatment and prevention of systemic symptoms was discussed. (Author)

Descriptors :   *CHEMOTHERAPEUTIC AGENTS, *EYE, *OPTHALMOLOGY, BLOOD, CHOLINESTERASE, DIAGNOSIS(MEDICINE), IODIDES, MEDICAL EXAMINATION, THERAPY

Distribution Statement : APPROVED FOR PUBLIC RELEASE