Accession Number : AD0290937

Title :   CEREBRAL EXCESS LACTATE PRODUCTION DURING HYPERVENTILATION OF ANESTHETIZED DOGS

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : CAIN,STEPHEN M.

Report Date : SEP 1962

Pagination or Media Count : 1

Abstract : Eight anesthetized, curarized dogs were ventilated to alveolar P(CO2) of 40, 20, and 10 mm. Hg. Blood samples were drawn from an artery and sagittal sinus and analyzed for P(CO2), P(O2), pH, hemoglobin saturation, lactic acid, and pyruvic acid. The vasoconstriction of the cerebral vessels was clearly demonstrated by the increased arteriovenous difference in hemoglobin saturation which increased on the average from 26% to 45% and to 48% during the two periods of hyperventilation. Sagittal sinus P(O2) declined from 41 mm. Hg during the control to 29 and to 25 mm. Hg with hyperventilation. Calculation of the cerebral excess lactate production from the measurements of lactic and pyruvic acids showed no significant increase with hyperventilation. The conclusion was made, with reservation, that cerebral oxygenation during even severe hyperventilation was sufficient to maintain normal oxidative metabolism. (Author)

Descriptors :   *BLOOD CIRCULATION, *CEREBRAL CORTEX, *OXYGEN, *POISONING, BLOOD VESSELS, CONTRACTION, DOGS, LABORATORY ANIMALS, METABOLISM, OXIDATION, PYRUVIC ACID

Distribution Statement : APPROVED FOR PUBLIC RELEASE