Accession Number : AD0293154

Title :   NEUROHUMORAL CONTROL OF THE PITUITARY

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s) : MCCANN,SAMUEL MCDONALD

Report Date : 21 NOV 1962

Pagination or Media Count : 1

Abstract : INVESTIGATIONS WERE CARRIED OUT TO MORE CLEARLY DEFINE THE HYPOTHALA IC CONTROL OVER THE ANTERIOR PITUITARY WITH PARTICULAR EMPHASIS ON ACTH and gonadotrophins. In the case of ACTH, very little residual ACTH secretion occurs in rats with hypophyses engrafted to the kidney capsule. We were unable to significantly alter the content of stored CRF by altering the titer of circulating corticoids. In the case of t e gonadotrophins, hypothalamic lesions lead to elevated secretion of LTH and markedly reduced secretion of LH. Hypothalamic stimulation augments LH secr tion and evidence is presented indicating that LH release may be trigg red by a hypothalamic LH-releasing factor. Since the conditions governing secretion of LH and ACTH were demonstrated to be different, it is postulated that the LH-RF is different from CRF. Additional studies dealt with the factors governing the secretion and storage of LH. (Author)

Descriptors :   *PITUITARY HORMONES, *THALAMUS, ADRENOCORTICOTROPIC HORMONE, PITUITARY GLAND, SECRETION

Distribution Statement : APPROVED FOR PUBLIC RELEASE