Accession Number : AD0403605

Title :   ON THE MECHANISM OF IMMUNOLOGIC SELF RECOGNITION,

Corporate Author : CALIFORNIA UNIV SANTA BARBARA

Personal Author(s) : Triplett,BWARD L.

Report Date : 27 FEB 1962

Pagination or Media Count : 6

Abstract : Experiments were performed which indicate that the ability of the immune system to recognize self is an acquired property gained by contact ing antigenic determinants of self tissues at some time during developmentt. The experiments consisted first of removing the buccal compon ent of the pituitary gland at a stage in devel opment before the gland had differentiated (begun to produce adult type proteins) but after the gland had been determined (possessed the ability to self-differentiate) and then growing the organism and the gland apart from one another until the organism was immunologically mature and the gland was differentiated. The gland and organism were then brought together as graft and host. In a significant percentage of cases the animal rejected its own hypophysis. Control ex periments excluded the possibility that the anti genicity of the graft had changed or that the animals had lost the ability to accept autografts. (Author)

Descriptors :   *IMMUNOLOGY, *TRANSPLANTATION, ANTIGEN ANTIBODY REACTIONS, GENETICS, THEORY, TEST METHODS, PITUITARY GLAND, AMPHIBIANS.

Distribution Statement : APPROVED FOR PUBLIC RELEASE