Accession Number : AD0410274

Title :   INTESTINAL ABSORPTION IN PORTAL HYPERTENSION.

Descriptive Note : Final rept., 1 Aug 61-31 July 63,

Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s) : Iber,by Frank L.

Report Date : 31 JUL 1963

Pagination or Media Count : 11

Abstract : The absorption of d-xylose was found to be normal in patients with portal hypertension and liver disease. Although the urine excretion of xylose after oral ingestion may be high, low, or normal these findings relate to (1) diminished metabol ism of xylose by the diseased liver and (2) sequestration of xylose in ascitic fluid. Meth ods using the Auto-Analyzer for the measurement of 3-methyl glucose (3MG) have shown that glucose and 3-MG compete equally for a transport system in the hamster gut sac, but that 3-MG is prefer entially excreted by a tubular mechanism in the dog. Bloo: levels after oral ingestion are the same for normal subjects and patients with liver disease and portal hypertension. There are in creased losses of serum albumin into the in testine in patients with cirrhosis and portal hypertension. Though this loss diminished in two patients following portacaval shunt, only about half of the patients with portal pressures above 200 mm. of water have increased losses. The absorption and subsequent excretion of water loads by patients with cirrhosis was investi gated. Water concentration in blood after oral water loads are diminished in cirrhosis but the causes for this have not yet been determined. (Author)

Descriptors :   (*INTESTINES, ABSORPTION), (*LIVER, HYPERTENSION), XYLOSE, DISEASES, URINE, EXCRETION, METABOLISM, GLUCOSE, LABORATORY ANIMALS, SERUM ALBUMIN, BLOOD, DOGS.

Distribution Statement : APPROVED FOR PUBLIC RELEASE