Accession Number : AD0413650

Title :   RESEARCH ON INTRA NEURONAL MECHANISMS FOR INFOR MATION STORAGE,

Corporate Author : GOTEBORG UNIV (SWEDEN)

Personal Author(s) : Hyden,Holger

Report Date : 31 MAR 1963

Pagination or Media Count : 7

Abstract : This report describes microchemical and bio physical analyses of neurons and the glia sur rounding each nerve cell body. The aid was to study, on the cellular level, the amount and composition of RNA, the amount of proteins, res piratory enzyme and ATP-ase activities during stimulation and in a learning situation in rats. Isolated, fresh cells were used for these studies. Inverse biochemical changes and result of kinetic studies showed that the neuron and its glia are linked in an energetic system. This inverse relationship between neuron and glia was shown to exist also with respect to RNA synthe sis. The rate of the enzyme reactions increased by 100% in the neuron due to stimulation. The glia, however, did not change in that respect. The anaerobic glycolysis was shown to increase in glia and decreathe neuron. This is supposed to reflect a priority of the neuron over the glia to get access to easily available energy through the respiratory chain, when the functional demands increase. (Author)

Descriptors :   (*LEARNING, BIOCHEMISTRY), (*BIOCHEMISTRY, LEARNING), ENZYMES, ADENOSINE, CELLS, STIMULATION(PHYSIOLOGY), RATS, RESPIRA, GLYCOLYSIS, ENERGY, PROTEINS, CHEMICAL, RIBONUCLEIC ACIDS, NERVE CELLS.

Distribution Statement : APPROVED FOR PUBLIC RELEASE