Accession Number : AD0419728

Title :   SOME METABOLIC EFFECTS OF METHIONINE TOXICITY IN THE RAT,

Corporate Author : ARCTIC AEROMEDICAL LAB FORT WAINWRIGHT ALASKA

Personal Author(s) : Klain,G. J. ; Vaughan,D. A. ; Vaughan,Lucile N.

Report Date : JUN 1963

Pagination or Media Count : 9

Abstract : Rats consuming a 15% casein diet containing 4.0% of DL methionine developed the following metabolic alterations in the liver: increased activities of arginase, tryptophan pyrrolase, glutamic-oxalacetic and pyruvic transaminase, decreased levels of DPN and slightly increased levels of total and neutral fat. However, the fat content approached a normal level at the end of the tenth week of the experimental period. Urinary excretion of a number of amino acids was also markedly increased. Supplementation of the high methionine diet with 4.0% of glycine decreased the activity of arginase and the levels of some amino acids in the urine. The data indicate that ingestion of excess methionine leads to a disorder in nitrogen metabolism, and that the supplemented glycine diminishes these catabolic processes. (Author)

Descriptors :   (*TOXICITY, METABOLISM), (*AMINO ACIDS, TOXICITY), ENZYMES, RATS, BIOSYNTHESIS, PHYSIOLOGY, MEDICAL RESEARCH

Distribution Statement : APPROVED FOR PUBLIC RELEASE