Accession Number : AD0429272

Title :   (NO TITLE).

Descriptive Note : Summary of final rept.

Corporate Author : MILAN UNIV (ITALY)

Report Date : DEC 1963

Pagination or Media Count : 1

Abstract : The experiments described deal with the effects of pineal and habenular extracts on renal excretion of Na, K, and water. These experiments were carried out on the assumption that the pineal gland would contain some of the substances active on hydro-mineral metabolism described in literature, such as adrenoglomerulotrophin. The total extracts of the cerebral cortex, pineal, and epithalamus reduce the ovarian ascorbic acid (A.A.O.) when assayed in Parlow's test. Serotonin in doses of 25 micron g has a depleting action on the ovarian ascorbic acid; melatonin does not. The extracts, 15 minutes after intravenous injection, increase the LH-like activity of the plasma in castrated rats treated with Estradiol and Progesterona. Serotonin in doses of 50 micron g did not produce this effect. The behavior of the extracts is that of a LH-releasing factor. (Author)

Descriptors :   (*ENDOCRINE GLANDS, SECRETION), CEREBRAL CORTEX, RATS, TISSUE EXTRACTS, BOVINES, SODIUM, POTASSIUM, WATER, KIDNEYS, EXCRETION, SEROTONIN, ASCORBIC ACID, HORMONES, PHYSIOLOGY

Distribution Statement : APPROVED FOR PUBLIC RELEASE