Accession Number : AD0430155

Title :   STUDIES ON THE CHEMOTHERAPY OF CHLOROQUINERESISTANT FALCIPARUM MALARIA, VIVAX MALARIA, AND PRIMAQUINE HEMOLYSIS.

Descriptive Note : Annual progress rept., 1 Aug 62-1 Jan 64,

Corporate Author : CHICAGO UNIV ILL

Personal Author(s) : Alving,Alf S.

Report Date : 01 JAN 1964

Pagination or Media Count : 12

Abstract : Detailed studies have been carried out with four strains of chloroquine-resistant P. falciparum. The strain from Colombia, South America is resistant to chloroquine, hydroxychloroquine, amodiaquin, and 377C54, and is sensitive to pyri methamine and quinine. The three strains from Southeast Asia are resistant to chloroquine, hydroxychloroquine, amodiaquin, atabrine, chlorguanide, and 377C54; these three strains vary in their response to pyrimethamine and quinine. Studies have also been carried out on (1) the activities of hexokinase and glyceraldehyde-3phosphate dehydrogenase during primaquine-induced hemolysis and (2) the relationship between the activities of these two enzymes and the age of the human red cell. (Author)

Descriptors :   (*CHEMOTHERAPEUTIC AGENTS, HEMOSPORIDIA), DISEASES, SENSITIVITY, ANTIMALARIALS, ERYTHROCYTES, ENZYMES, HEMOLYSIS, PHYSIOLOGY, DRUGS

Distribution Statement : APPROVED FOR PUBLIC RELEASE