Accession Number : AD0433770

Title :   ISOLATION, IDENTIFICATION AND PHYSIOLOGY OF A POSTULATED HORMONE CAPABLE OF INDUCING EXCRETION OF SODIUM,

Descriptive Note : Annual progress rept., 1 Mar 63-29 Feb 64,

Corporate Author : MICHIGAN UNIV ANN ARBOR

Personal Author(s) : Conn,J. W.

Report Date : 29 FEB 1964

Pagination or Media Count : 7

Abstract : Intramuscular administration of aldosterone to normal subjects produces an initial period of sodium and water retention, followed by the socalled 'escape' from retention. At this time there is a supranormal rate of urinary sodium excretion (UNaV) in response to an intravenous infusion of physiological saline. Three subjects were studied after simultaneous administration of antidiuretic hormone (ADH) and aldosterone. The rate of sodium excretion was 1.24=.22 mEq/min. Similar results were obtained after acute intravenous ADH infusion or chronic intramuscular pitressin therapy. When oral water load preceded the saline infusions, aldosterone resulted in the usual bimodal effect on sodium excretion. The results are compitible with the concept of hormonal control of the mechanism of escape, involving a humoral effect upon the renal tubular transport of sodium. Studies now in progress are designed to evaluate directly the urinary excretion of a salt losing hormone in patients with primary aldosteronism and in normal subjects given aldosterone. Preliminary data suggest that post infusion urine from subjects receiving aldosterone results in a significant natriuresis when injected into normal rats. (Author)

Descriptors :   (*SODIUM, EXCRETION), (*HORMONES, PHYSIOLOGY), IDENTIFICATION, PURIFICATION, RATS, THERAPY, METABOLISM

Distribution Statement : APPROVED FOR PUBLIC RELEASE