Accession Number : AD0434058

Title :   SYNTHESIS OF POTENTIAL ANTIRADIATION DRUGS.

Descriptive Note : Annual Summary Rept. (Final) 1 Oct 62-31 Mar 64,

Corporate Author : STANFORD MEDICAL CENTER PALO ALTO CALIF

Personal Author(s) : Goodman,Leon ; Christensen,James E. ; Holton,SandraL.

Report Date : 31 MAR 1964

Pagination or Media Count : 1289

Abstract : The synthesis of 6-acetamido-1,2,3,4-tetra-0acetyl-6-deoxy- -L-idothiapyranose was completed. This represents an interesting type of sugar that contains sulfur as the heterocyclic ring atom and possesses a neighboring N-acetyl group. An extension of this synthetic method can probably be used to give the free sugar, 6-amino-6-deoxy-5-thio-L-idose, an interesting substituted Beta-mercaptoethylamine. Tryptamine was mercaptoethylated to yield N-(2-mercaptoethyl)-tryptamine hydrochloride. A number of ethylenimines were converted to thiols, Bunte salts, and isothiuronium salts. The most extensive group of compounds of this type came from the reaction of DL-propylenimine with meso1,2:3,4-diepoxybutane that gave three stereoisomeric bis-aziridines. The bisaziridines in turn were converted to the respective bis-thiols, bis-Bunte salts, and bis-isothiuronium salts. (Author)

Descriptors :   (*RADIOPROTECTIVE AGENTS, SYNTHESIS), (*DRUGS, RADIOPROTECTIVE AGENTS), (*THIOLS, RADIOPROTECTIVE AGENTS), SULFUR COMPOUNDS, HETEROCYCLIC COMPOUNDS, CHEMICAL PROPERTIES, CHEMISTRY

Distribution Statement : APPROVED FOR PUBLIC RELEASE