Accession Number : AD0436654

Title :   PREVENTION OF THE DEVELOPMENT OF MICROBIAL RESISTANCE TO DRUGS,

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA SCHOOL OF MEDICINE

Personal Author(s) : Drabble,W. T. ; Sevag,M. G.

Report Date : 1943

Pagination or Media Count : 5

Abstract : The development of drug-resistant populations of bacteria from sensitive cells of Staphylococcus aureus and Aerobacter aerogenes was prevented in growth systems containing the polyamines, spermine or spermidine, and streptomycin, penicillin, or erythromycin. The same number of cells readily developed resistance if inoculated into medium without the polyamine. Cells grown previously in spermine alone were also inhibited by the above combinations. The growth of fully resistant cells, however, was not affected by the combined presence of spermine and an antibiotic. This effect was not comparable to the usual synergism between two drugs. Penicillinresistant S. aureus was prevented from yielding a population resistant to streptomycin in combination with spermine. (Author)

Descriptors :   (*ANTIBIOTICS, INHIBITION), (*CHEMOTHERAPY, IMMUNITY), STAPHYLOCOCCUS AUREUS, AEROBACTER AEROGENES, STREPTOMYCINS, AMINES, ANTIGEN ANTIBODY REACTIONS

Distribution Statement : APPROVED FOR PUBLIC RELEASE