Accession Number : AD0444590

Title :   THE EFFECT OF OXYGEN ON GLUTAMIC ACID DECARBOXYLASE AND GAMMA-AMINOBUTYRIC ACID-ALPHAKETOGLUTARIC ACID TRANSAMINASE ACTIVITIES IN RAT BRAIN HOMOGENATES,

Corporate Author : DEFENCE RESEARCH MEDICAL LABS TORONTO (ONTARIO)

Personal Author(s) : Wood,J. D. ; Watson,W. J.

Report Date : 11 OCT 1963

Pagination or Media Count : 3

Abstract : Gamma-aminobutyric acid (GABA) is found in appreciable amounts in mammals only in the central nervous system, where it is believed to play important roles in oxidative metabolism and in the regulation and transmission of nerve impulses. GABA in the brain is formed from glutamic acid by decarboxylation and is catabolized by a transamination reaction with alphaketoglutaric acid, the latter enzyme forming part of the well-known GABA shunt pathway. The level of GABA in the brain may therefore be regulated by varying the relative reaction rates of these two enzyme systems referred to as GAD and GABA-T respectively. Since no data are available concerning the relative sensitivity of GAD and GABA-T to oxygen the present investigation was initiated to study this aspect of the problem. (Author)

Descriptors :   (*ENZYMES, BRAIN), (*BRAIN, METABOLISM), (*AMINO ACIDS, BRAIN), OXYGEN, GLUTAMIC ACID, RATS, CARBOXYLIC ACIDS, KETONES, CANADA

Distribution Statement : APPROVED FOR PUBLIC RELEASE