Accession Number : AD0449638

Title :   SOME PRODUCTS OF THE DEGRADATION OF BLOOD GROUP SUBSTANCES BY ALKALINE BOROHYDRIDE,

Corporate Author : COLUMBIA UNIV NEW YORK COLL OF PHYSICIANS AND SURGEONS

Personal Author(s) : Lloyd, Kenneth O. ; Kabat, Elvin A.

Report Date : 01 JUN 1964

Pagination or Media Count : 6

Abstract : Alkaline borohydride produces fragments frnm blood group substances, some of which appear to contain the entire antigenic determinants. From the immunochemical and analytical properties of these partially purified fragments possible structures for these determinants were suggested. For example, A3 was thought to be a hexa or hepta-saccharide consisting of 1 mole each of N-acetyl-D-galactosamine, D-galactose, N-acetyl-D-glucosamine, 2 moles of L-fucose, and a reduced end group. Some of these fractions have now been further purified and the action of alkaline borohydride on hog mucin (A+H) substance studied. A fucose containing oligosaccharide was obtained from A substance. (Author)

Descriptors :   (*BIOLOGICAL PRODUCTS, CHROMATOGRAPHIC ANALYSIS), (*BOROHYDRIDES, BIOCHEMISTRY), DEGRADATION, FRAGMENTATION, MOLECULAR STRUCTURE, BIOLOGICAL PRODUCTS, SWINE, BLOOD GROUPS, CARBOHYDRATES.

Distribution Statement : APPROVED FOR PUBLIC RELEASE