Accession Number : AD0451574

Title :   CHLOROQUINE SUICIDE,

Corporate Author : ARMED FORCES INST OF PATHOLOGY WASHINGTON DC

Personal Author(s) : Kiel, Frank W.

Report Date : 1964

Pagination or Media Count : 3

Abstract : Thirteen cases of death due to chloroquine overdosage were encountered involving individuals in the Far East on antimalarial treatment and a patient with arthritis taking chloroquine for symptomatic relief. Suicide was the most likely manner of death in all cases. These patients showed a rapid course, with death often occuring in less than two hours. Autopsy findings were unrewarding, unless the pills could be recovered from the stomach. Toxicologic analysis was used to confirm chloroquine poisoning as the cause of death, the fatal cases showing a twenty-fold increase in tissue concentration over the therapeutic level. In a drug of reputedly low toxicity like chloroquine, its uses as a suicidal agent indicates that control of large supplies of the tablets should be maintained with care. (Author)

Descriptors :   (*PHOSPHATE COMPOUNDS, LETHAL DOSAGE), DRUGS, TOXICITY, PATHOLOGY, PHARMACOLOGY, DOSE RATE, MILITARY PERSONNEL, BLOOD ANALYSIS, TISSUES (BIOLOGY), QUINOLINES.

Distribution Statement : APPROVED FOR PUBLIC RELEASE