Accession Number : AD0456165

Title :   BETA-PHENETHYL ALCOHOL INHIBITION OF BACILLUS

Corporate Author : ARMY CHEMICAL CORPS FORT DETRICK MD BIOLOGICAL LABS

Personal Author(s) : Mendelson, Neil H

PDF Url : AD0456165

Report Date : Jan 1965

Pagination or Media Count : 23

Abstract : Initial studies of beta-phenethyl alcohol (PEA) inhibition in Bacillus subtilis strain 168 indole reveal that concentrations necessary to inhibit growth fall within very narrow limits. Under our conditions stationary phase cells of strain 168 could not undergo inhibition without concomitant loss of viability. Log-phase cells were capable of survival in PEA but unable to resume log-phase growth when removed from PEA. Strain W23 responded differently in that inhibited cells were found capable of recovery when removed from the inhibitor. Cells of different stages of growth exhibited differences in response to PEA inhibition and to relief from PEA inhibition. Chemical studies of inhibited W23 cells show a rapid cessation of DNA, RNA, and protein synthesis. Cells recovering from inhibition were found to lag 1 hour prior to initiation of synthesis. No DNA synthesis was detected throughout the 2-hour period of recovery examined.

Descriptors :   *BACILLUS SUBTILIS, ALCOHOLS, BIOSYNTHESIS, CHROMOSOMES, CULTURE MEDIA, DEOXYRIBONUCLEIC ACIDS, ETHERS, GROWTH(PHYSIOLOGY), INHIBITION, PHENOLS, PHYSIOLOGY, RIBONUCLEIC ACIDS

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE