Accession Number : AD0466647

Title :   ASCORBIC ACID, BIOLOGICAL FUNCTION AND CHEMISTRY.

Descriptive Note : Final rept.,

Corporate Author : COLORADO UNIV AT BOULDER DEPT OF CHEMISTRY

Personal Author(s) : Bell, E. ; Levandoski, N. ; Tolbert, Bert M.

Report Date : 30 JUN 1965

Pagination or Media Count : 12

Abstract : The objective of this work is to initiate a study on the biochemistry of ascorbic acid. Two major areas have been covered. (a) What are the sequence of events and chemical nature of the oxidation of ascorbic acid (AsH2) to monodehydroascorbic acid (AsH) to dehydroascorbic acid (dAs). (b) What are the metabolically active forms of vitamin C and their role on an enzymic level. Our progress in this work is detailed in three sections of this report: (1) Study of Ascorbate Oxidation. (2) Synthesis of Tritium Labeled Ascorbates. (3) The Ascorbate Enzyme System. In addition, cooperative work on ascorbate assays has been done in connection with the Chemical Division of the Medical Research and Nutrition Laboratories of the Fitzsimons Army Hospital, Denver. (Author)

Descriptors :   (*ASCORBIC ACID, BIOCHEMISTRY), (*OXIDATION, ASCORBIC ACID), METABOLISM, SYNTHESIS(CHEMISTRY), INFRARED SPECTRA, MASS SPECTROSCOPY, NUCLEAR MAGNETIC RESONANCE, TRITIATED COMPOUNDS, MOLECULAR ISOMERISM, ATOMIC ORBITALS, LINE SPECTRA, PROTONS, ELECTRONS, TRANSPORT PROPERTIES, ENZYMES, ADENINE, NUCLEOTIDES, NICOTINIC ACID, AMIDES, LABELED SUBSTANCES.

Distribution Statement : APPROVED FOR PUBLIC RELEASE