Accession Number : AD0466946

Title :   STOICHIOMETRIC RELATIONSHIPS IN CORTISOL-INDUCED SWELLING OF RAT LIVER MITOCHONDRIA,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : DeVenuto, F. ; Westpahl, U.

Report Date : 31 MAR 1965

Pagination or Media Count : 2

Abstract : The influence of cortisol on the swelling of rat liver mitochondria was studied by measuring the changes of optical density of mitochondrial suspensions in the presence and in the absence of the steroid. The results show that an increase of the swelling rate under the influence of cortisol is apparent 12 and 44 minutes after mixing the hormones and the mitochondrial suspension; the effect disappears after a few hours. Maximal acceleration is observed at 1/10 to the 9th power M cortisol. At this steroid concentration the ratio of cortisol molecules per mitochondrion is approximately 1000:1. This is the same order of magnitude that has previously been observed in spontaneous beinding of cortisol to rat liver mitochondria. (Author)

Descriptors :   (*CORTICOSTEROID AGENTS, METABOLISM), (*BIOCHEMISTRY, CORTICOSTEROID AGENTS), LIVER, MITOCHONDRIA, OPTICAL PHENOMENA, DENSITY, MOLECULAR PROPERTIES, PERMEABILITY, VOLUME, RATS.

Distribution Statement : APPROVED FOR PUBLIC RELEASE