Accession Number : AD0466977

Title :   RADIATION EFFECTS ON RENAL ENLARGEMENT IN THE MOUSE,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CA

Personal Author(s) : Phillips, Theodore L. ; Vaeth, J. M.

Report Date : 09 MAY 1965

Pagination or Media Count : 8

Abstract : Weanling female CF-1 mice were subjected to unilateral nephrectomy followed in 3 hours by doses of total body radiation of 500 and 600 r. Other groups received doses of 500, 600, and 1350 r to half the abdomen over the remaining kidney 3 hours following unilateral nephrectomy. The effects of these procedures on the renal weight and body weight were measured 3 weeks after surgery. Control kidneys increased 80% in weight while 1350 r applied locally to the abdomen limited the weight gain to 55%, and total body exposure to 600 r to 53%. When nephrectomy was not performed, the kidney increased 34% in weight due to animal growth. Local exposure of one kidney to 1350 r limited the weight gain of both equally to 20%. When the results are considered on the basis of renal weight to body weight ratio (R/B%), no significant changes were produced by irradiation. Nephrectomy alone brought the ratio of the remaining kidney from .64% to 95% and the irradiated groups attained from .93% to 1.0%. When the animals are grouped according to weight gain, those gaining over 6% show no significant radiation effect on renal weight gain. It is concluded that radiation in these dose ranges has on measurable direct effect on renal weight gain at 3 weeks after nephrectomy, but acts by systemic means related to decreased food intake and poor general condition. (Author)

Descriptors :   (*RADIATION EFFECTS, KIDNEYS), (*KIDNEYS, RADIATION EFFECTS), WEIGHT, PATHOLOGY, RADIATION DOSAGE, SURGERY, BODY WEIGHT, MICE, STARVATION, DEOXYRIBONUCLEIC ACIDS, BIOSYNTHESIS.

Distribution Statement : APPROVED FOR PUBLIC RELEASE