Accession Number : AD0467861

Title :   NITROGEN-15 MAGNETIC RESONANCE SPECTROSCOPY. VI. PYRIMIDINE DERIVATIVES,

Corporate Author : CALIFORNIA INST OF TECH PASADENA GATES AND CRELLIN LABS OF CHEMISTRY

Personal Author(s) : Roberts, Bryan W. ; Lambert, Joseph B. ; Roberts, John D.

Report Date : JUL 1965

Pagination or Media Count : 14

Abstract : Proton and nitrogen-15 magnetic resonance spectra of several derivatives of pyrimidine have been studied. Long-range (15)N-H couplings were observed in uracil-(15)N2, 2,4-dichloropyrimidine-(15)N2, 2,4-dimethoxypyrimidine-(15)N2, 1-methyl-4-methoxy-2-pyrimidone-(15)N2, and 1-methylcytosine-(15)N3. A particularly large (15)N(1)-C-H coupling (12.5 c.p.s.) has been observed in 2,4-dichloropyrimidine-(15)N2. 1-Methylcytosine-(15)N3 has been shown to exist in the amino tautomeric form and to protonate at N(3) in agreement with previously reported work on 1-methylcytosine labeled only in the amino group. (Author)

Descriptors :   (*PYRIMIDINES, NUCLEAR MAGNETIC RESONANCE), CHLORINE COMPOUNDS, PROTONS, NITROGEN, PURINES, NUCLEOSIDES.

Distribution Statement : APPROVED FOR PUBLIC RELEASE