Accession Number : AD0468979

Title :   AGE AND DOSE DEPENDENCE OF BONE GROWTH RETARDATION INDUCED BY X-IRRADIATION,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CA

Personal Author(s) : Phillips, Richard D. ; Kimeldorf, Donald J.

Report Date : 01 JUL 1965

Pagination or Media Count : 24

Abstract : The quantitative aspects of bone growth retardation in rats after x-irradiation were determined with respect to radiation dose and exposure age. The deficits in femur and tibia growth at 60 days after irradiation increased exponentially with a linear increase in dose. The growth deficits were also a function of exposure age, increasing exponentially with the reciprocal of exposure age. The information obtained from the dose-response and ageresponse relationships was used to derive an equation which could be used to predict the bone growth decrement on the basis of the age at exposure and the dose administered. The general equation for bone growth retardation was found to give a good estimation of effect within the dose range of 100 to 680 rads for exposure ages of 24 to 58 days. (Author)

Descriptors :   (*RADIATION EFFECTS, BONES), (*BONES, RADIATION EFFECTS), NOSE(ANATOMY), GROWTH(PHYSIOLOGY), INHIBITION, X RAYS, RADIATION DOSAGE, RATS, AGING(PHYSIOLOGY), RADIOBIOLOGY, RADIATION INJURIES, MATHEMATICAL ANALYSIS.

Distribution Statement : APPROVED FOR PUBLIC RELEASE